Chen, Han-Sen, Su-Hua Qi, and Jian-Gang Shen. “One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke.”Current Neuropharmacology15.1 (2017): 134–156.PMC. Web. 26 July 2017.
Chen, Han-Sen, Su-Hua Qi, and Jian-Gang Shen. “One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke.”Current Neuropharmacology15.1 (2017): 134–156.PMC. Web. 26 July 2017.以上表格总结了可能与t-PA 联用的中药单体及其可能作用的多个靶点， 包括mmp-9, NF-KB, HMGB1,ROS, RNS, NMDAR等