METHOD FOR PREPARING CHEMICAL COMPOUNDS OF INTERES

专利名称：METHOD FOR PREPARING CHEMICAL

COMPOUNDS OF INTEREST BY

NUCLEOPHILIC AROMATIC SUBSTITUTIONOF AROMATIC CARBOXYLIC ACID

DERIVATIVES SUPPORTING AT LEAST ONEELECTRO-ATTRACTIVE GROUP

发明人：Jacques Mortier,Anne-Sophie

Castanet,Mickael Belaud-Rotureau

申请号：US13578673申请日：20110217

公开号：US20120316337A1公开日：20121213

摘要：Method for preparing carboxylic acid derivatives by aromatic nucleophilicsubstitution, in which a carboxylic acid derivative having a single carboxyl functional group,or one of the salts thereof, the carboxylic acid derivative having, in the ortho position ofthe carboxyl functional group, a leaving group, which is preferably an atom of fluorine orof chlorine or an alkoxy group, chiral or not, preferably a methoxy group, the carboxylicacid derivative not being substituted by an electro attractive group other than theleaving group if any; is reacted with a reactant MNu, where M is a metal and Nu is anucleophile, chiral or not, the aromatic nucleophilic substitution reaction being carriedout without a catalyst and without a step of protecting/deprotecting the acid functionalgroup of the starting compound.

申请人：Jacques Mortier,Anne-Sophie Castanet,Mickael Belaud-Rotureau

地址：Ecommoy FR,Le Mans FR,Le Mans FR

国籍：FR,FR,FR

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