METHODS AND COMPOSITIONS FOR PREDICTING THERAPEUTI

专利名称：METHODS AND COMPOSITIONS FOR

PREDICTING THERAPEUTIC EFFICACY OFKINASE INHIBITORS IN PATIENTS WITHMYELODYSPLASTIC SYNDROME ORRELATED DISORDERS

发明人：TYCKO, Benjamin,RAZA, Azra,WILHELM,

Francois

申请号：EP14804442.3申请日：20140528公开号：EP3004387A4公开日：20170412

摘要：The invention discloses a diagnostic method for predicting the therapeuticefficacy of a broad specificity kinase inhibitor in a subject with refractory cancercomprising determining the locus-specific DNA methylation profile of the subject,wherein the locus-specific DNA methylation profile predicts the therapeutic efficacy of abroad specificity kinase inhibitor for treatment of a subject with refractory cancer.

申请人：Onconova Therapeutics, Inc.,The Trustees of Columbia University in the City ofNew York

地址：375 Pheasant Run Newtown, PA 140 US,412 Low Memorial Library 535 West116th Street New York, New York 10027 US

国籍：US,US

代理机构：HGF Limited

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