专利名称：Sertraline hydrochloride polymorphs发明人：Eduard Schwartz,Tamar Nidam,Anita
Liberman,Marioara Mendelovici,JudithAronhime,Claude Singer,Evgeni Valdman
申请号：US11415830申请日：20060501
公开号：US20060241189A1公开日：20061026
摘要：The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X ofsertraline hydrochloride and novel methods for their preparation. According to thepresent invention, sertraline hydrochloride polymorph II may be produced by slurryingsertraline hydrochloride polymorph VI in aprotic organic solvent. Sertraline
hydrochloride polymorphic form III may be produced by heating sertraline hydrochloridepolymorphs V and VI. Sertraline hydrochloride forms V and VI may be produced fromeither sertraline hydrochloride or sertraline base by crystallization. Sertraline
hydrochloride Form VII may be produced by suspending sertraline chloride polymorph Vin water, followed by filtration. Sertraline hydrochloride Forms VIII and IX may beproduced by suspending sertraline base in water followed by acidification and filtration.Sertraline hydrochloride Form X may be produced by suspending sertralinehydrochloride in benzyl alcohol with heating, followed by filtration.
申请人：Eduard Schwartz,Tamar Nidam,Anita Liberman,Marioara Mendelovici,JudithAronhime,Claude Singer,Evgeni Valdman
地址：Rechovot IL,Yehud IL,Tel-Aviv IL,Rechovot IL,Rehovot 44242 IL,Kfar Saba
IL,Petah Tikva IL
国籍：IL,IL,IL,IL,IL,IL,IL
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