Histamine h2 receptor and uses

专利名称：Histamine h2 receptor and uses发明人：KARL F. KOVACS,GILBERT JAY申请号：AU2002357243申请日：20021217公开号：AU2002357243A8公开日：20030630

摘要：The present invention relates to the histamine H2 receptor (H2R), a member ofthe G-protein-coupled heptahelical receptor family. This novel H2 receptor codes for anovel carboxy-terminal tail which imparts important regulatory functions to the receptor,e.g., in down-regulation, signal transduction, and in coupling the activity of the H2R todownstream effector molecules, such as G-protein-coupled receptor kinases (GRK). Thepresent invention relates to all facets of this new form of the H2R receptor, includingnucleic acids that encode it, H2R polypeptides, binding-partners thereto, as well as its usein research, diagnosis, drug discovery, validation, and targeting, therapy, and clinicalmedicine.

申请人：ORIGENE TECHNOLOGIES, INC.

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