PROCESS FOR PREPARING PERINDOPRIL ERBUMINE

专利名称：PROCESS FOR PREPARING PERINDOPRIL

ERBUMINE

发明人：PALOMO NICOLAU, Francisco,DE LEON,

Dorcas

申请号：EP05818419.3申请日：20051215公开号：EP1833788A1公开日：20070919

摘要：The present invention relates to a new process for preparing perindoprilerbumine (I), useful in the treatment of hypertension. The invention relates to obtaining1-[(2S)-2-[[(1S)-1(ethoxycarbonyl)butyl]amino]-1-propionyl] (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylic acid, tert-butylamine salt that comprises reacting an active ester of N-[2(S)-(ethoxycarbonyl)butyl]-L-alanine with an organic salt of perhydroindole-2-carboxylicacid, followed by the addition of t-butylamine and an acid to the reaction medium, in anyorder, or else a salt formed from an acid and tert-butylamine, and separating theproduct by conventional means.

申请人：Quimica Sintetica, S.A.

地址：Gran Via de Carles III, 98, 7è., Edifici Trade 08028 Barcelona ES

国籍：ES

代理机构：Ponti Sales, Adelaida

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